1.刘铁民

刘铁民，复旦大学生命科学学院教授，博导。多伦多大学取得博士学位，德克萨斯大学西南医学中心(美国)博士后，中国生物物理学会副秘书长，国家自然科学基金评审专家。 

一、主持项目  

[1] 国家自然科学基金应急管理项目，31842034，代谢基础研究资助现状和未来重点突破方向，2019/1-2019/12，50万，在研，主持

[2] 遗传工程国家重点实验室开放课题, SKLGE1803, 调控脂肪发育、维持脂稳态关键基因的筛选与遗传机制研究，2018/7-2020/12，12万，在研，主持

[3] 上海市浦江人才计划，18PJ1400700，黑皮质素4受体通路对米色脂肪组织调控的机制研究，2018/7-2020/6，20万，在研，主持

[4] 上海市2018年度“科技创新行动计划”实验动物研究领域项目，18140901300，肌生成抑制素MSTN相关转基因小鼠模型的开发，2018/5-2021/4，30万，在研，主持

[5] 南京大学医药生物技术国家重点实验室开放课题，KF-GN-201701，脑干中羟色胺2C受体在调节能量代谢中的作用，2018/1-2019/12，20万，在研，主持

[6] 国家自然科学基金重大研究计划，91749104，黑皮质素-4受体对脂肪代谢调节在衰老中作用机制的研究，2018/1-2020/12，60万，在研，主持

[7] NCRP Winter 2014 Scientist Development Award，14SDG20370016，Autonomic regulation of adipocyte metabolism by melanocortin-4 receptors，2014/07-2018/06，308,000美金，已结题，主持

[8] Canadian Diabetes Association Post-doctoral Fellowship，NOD_PF-1-14-4646-TL，Autonomic regulation of adipocyte metabolism by melanocortin-4 receptors，2014/07-2015/06，45,000美金，已结题，主持

[9] American Diabetes Association Post-doctoral Fellowship，7-11-MN-16，5-HT2C receptors in brainstem neurons regulate glucose homeostasis，2012/3-2014/7，1 00,000美金，已结题，主持

二、以第一/通讯作者发表的SCI论文  （*通讯作者）  

[1]  Tiemin Liu#, Bryan Lo, Pam Speight, and Mel Silverman, Transmembrane IV of the high-affinity sodium-glucose cotransporter participates in sugar binding, Am J Physiol Cell Physiol, 2008.7.30, 295(1): C64–C72.

[2]  TieminLiu#, PamSpeight, MelSilverman, Reanalysis of structure/function correlations in the region of transmembrane segments 4 and 5 of the rabbit sodium/glucose cotransporter, Biochem Biophys Res Commun, 2009.1.2, 378 (1), 133-138

[3]  TieminLiu#, DanielKrofchick, MelSilverman, Effects on conformational states of the rabbit sodium/glucose cotransporter through modulation of polarity and charge at glutamine 457, Biophysical Journal, 2009.1.21, 96 (2), 748-760

[4]  Tiemin Liu#,Dong Kong,Bhavik P. Shah,Chianping Ye,Shuichi Koda,Arpiar Saunders,Jun B.Ding,Zongfang Yang,Bernardo L.Sabatini,Bradford B.Lowell,Fasting activation of AgRP neurons requires NMDA receptors andinvolvesspinogenesis and increased excitatory tone,Neuron,2012.2.9,73(3): 511~522

[5]  Tiemin Liu#,Qian Wang,Eric D.Berglund,Qingchun Tong,Action ofNeurotransmitter: A Key to Unlock the AgRP Neuron Feeding Circuit,Frontiers in Neuroscience,2013.1.21,6:200

[6]  Tiemin Liu#,Joel K.Elmquist,Kevin W.Williams,Mrap2: an accessory protein linked to obesity,Cell Metabolism,2013.9.3,8(3):309~311

[7]  Eric D.Berglund#,Tiemin Liu#,ingxing Kong#,Jong-Woo Sohn,Linh Vong,Zhuo Deng,Charlotte E. Lee,Syann Lee,Kevin W.Williams,David P.Olson,Philipp E.Scherer,Bradford B.Lowell,Joel K.Elmquist,Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia,Nature Neuroscience,2014.6.8,17(7):911~913

[8] Kevin W.Williams#,Tiemin Liu#,Xingxing Kong#,Makoto Fukuda,Yingfeng Deng,Eric D.Berglund,Zhuo Deng,Yong Gao,Jong-Woo Sohn,Lin Jia,Teppei Fujikawa,Daisuke Kohno,Michael M.Scott,Syann Lee,Lee Charlotte E.,Kai Sun,Yongsheng Chang,Philipp E.Scherer,Joel K.Elmquist,Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis,Cell Metabolism,2014.9.2,20(3):471~482

[9] Jia Sun#,Yong Gao#,Ting Yao#,Yiru Huang,Zhenyan He,Xingxing Kong,Yu Kai-Jiang,Rui-Tao Wang,Hongbo Guo,Jianqun Yan,Yongsheng Chang,Hong Chen,Philipp E.Scherer,Tiemin Liu*,Kevin W.Williams*,Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons, MolMetab,2016.08.18,5(10):882~891

[10]  Rui-Tao Wang#,Xue-SongLi,Ji-Rong Zhang,Yuxiang Sun,Kai-Jiang Yu,Tiemin Liu*,Bone mineral density is associated with left ventricular diastolic function in women,Clin Cardiol,2016.10.07,39(12):709~714

[11]  Jia Sun#,Yuting Ruan#,Ming Wang,Rongping Chen,Na Yu,Lei Sun,Tiemin Liu* ,Hong Chen* ,Differentially expressed circulating LncRNAs and mRNAidentified by microarray analysis in obese patients,Sci Rep,2016.10.21,6:35 421~35320

[12]  Yong Gao#,Ting Yao#,Zhuo Deng#,Jong-Woo Sohn#,Jia Sun,Yiru Huang,Xingxing Kong,Kai-Jiang Yu,Rui-Tao Wang,Hong Chen,Hongbo Guo,Jianqun Yan,Kathryn A.Cunningham,Yongsheng Chang*,Tiemin Liu*,Kevin W.Williams*,TrpC5 Mediates Acute Leptin and Serotonin Effects via Pomc Neurons,Cell Rep,2017.01.1718(3):583~592

[13]  Xingxing Kong#,Kevin W.Williams,Tiemin Liu*,Genetic Mouse Models: The Powerful Tools to Study Fat Tissues,Methods Mol Biol,2017.02.28，99~107

[14]  Yao Ting#,Zhuo Deng#,Yong Gao#,Jia Sun#,Xingxing Kong,Yiru Huang,Zhenyan He,Yanchao Xu,Yongsheng Chang,Yongsheng Yu,Brianna G.Findley,Eric D.Berglund,Rui-Tao Wang,Hongbo Guo,Hong Chen,Xu Li,Randal J.Kaufman,Jianqun Yan*,Tiemin Liu*,Kevin W.Williams*,Ire1α in Pomc Neurons Is Required for Thermogenesis and Glycemia,Diabetes,2017.03.31，66(3 ):663~673

[15] Wen-Jie Shen#,Ting Yao#,Xingxing Kong,Kevin W.Williams,Tiemin Liu*,Melanocortin neurons: Multiple routes to regulation of metabolism,Bioch imBiophys Acta,2017.05.09，S0925-4439(17):30144~30148

[16]  Xingxing Kong#, Ting Yao#, Peng Zhou, Lawrence Kazak, Danielle Tenen, Anna Lyubetskaya, Brian A. Dawes, Linus Tsai, Barbara B. Kahn, Bruce M. Spiegelman, Tiemin Liu*, and Evan D. Rosen*，Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin，Cell Metabolism,2018.10.02,28(4):631-643

[17] Qun Wei1#, Yi-Feng Gu#,Qing-Jun Zhang, Helena Yu, Yan Peng, Kevin W. Williams,Ruitao Wang, Kajiang Yu, Tiemin Liu*, and Zhi-Ping Liu*,Lztfl1/BBS17 controls energy homeostasis byregulating the leptin signaling in the hypothalamicneurons, Journal of Molecular Cell Biology, 2018.10.1, 10（5）：402-410

[18] Shanshan Guo#, Yiru Huang#,Yan Zhang,He Huang, Shangyu Hong*, Tiemin Liu*, Impacts of exercise intervention on different diseases and organ functions in mice, Journal of Sport and Health Science, 2019，inpress